The Galiuro Mountains are a large sky island mountain range of southeast Arizona, United States. It is a northerly mountain range in the Madrean Sky Islands region of southeast Arizona, northern Sonora in northwestern Mexico, and the extreme southwest (the "bootheel") of New Mexico.

The range is noted for its height and ruggedness. The Aravaipa Canyon Wilderness encompasses the north perimeter of the range, and the large Galiuro Wilderness covers the central-south. To the south, the Galiuro Wilderness borders the Redfield Canyon Wilderness. A river valley borders the range to the southwest, and Aravaipa Creek and Valley border its northeast.